INGM

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Junior biological data analyst. Gene expression, statistics and computational biology (Ref. IBBIO).

Description

A position for junior biological data analyst is available starting spring/summer 2012 in the Integrative Biology group to join a multidisciplinary effort for the comprehension of the molecular mechanisms and regulatory networks underlying T cell differentiation in the human immune system, and to serve as data analyst to alleviate the computational needs of different projects.

Qualifications

We welcome candidates holding a degree in informatics, bioinformatics, biological sciences or similar. The successful candidate will be working with medium to high throughput-screening technologies such as RTqPCR arrays, OpenArrays and Microarrays and will use standardized data analysis pipelines for genes/miRNA prioritization.

Candidates coming from non-informatics disciplines must be willing to be involved in a strongly computer-based job. Familiarity with the concept of gene expression and PCR is required, as well as a good computer literacy; previous experience in gene expression, biological network and biochemical pathways analysis will be considered a plus. Knowledge of R/Bioconductor, MySQL or databases in general is beneficial and will be strongly welcomed.

If interested, please send your CV, motivation letter and references via email to dr. Riccardo L. Rossi (rossi@ingm.org).

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Junior biological data analyst. Deep sequencing analysis and developing (Ref. IBDEV).

Description

A position for junior data analyst and developer is available starting spring/summer 2012 in the Integrative Biology group to join a multidisciplinary effort for the comprehension of the molecular mechanisms and regulatory networks underlying T cell differentiation in the human immune system, and to serve as data analyst to alleviate the computational needs of different projects.

We welcome candidates holding a degree in informatics, bioinformatics, statistics, physics, mathematics. The successful candidate will be working with high throughput-sequencing technology such as Illumina HiScanSQ and will use and develop custom data analysis pipelines. He/she will be involved in different projects and will be exposed to the analysis of different kind of immunology-related data as well as medical statistics and large datasets handling.

Qualifications

Knowledge of at least a programming language (Ruby, C, C++, Java, Python), R/Bioconductor, Bash Linux and databases MySQL or PostgreSQL are required.

If interested, please send your CV, motivation letter and references via email to dr. Raoul J.P. Bonnal (bonnal@ingm.org).

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Bionformatics Post doctoral position in the Epigenetic Unit

Description
A 3-year post-doctoral position is available starting from September 2012 in the group of Dr. Alessio Zippo at INGM in Milan, Italy. Our newly established team investigates the epigenetic mechanisms that dictate the establishment and the maintenance of stem cell identity. We aim to dissect the molecular mechanisms through which transcription factors mediate the epigenetic responses to environmental signaling in Embryonic and Cancer Stem Cells.
We are seeking highly motivated candidates that will be working closely with a group of biologists and be involved in designing and analysing dataset obtained from ChIP-seq and RNA-seq studies. Moreover, you will have the possibility to closely interact with scientists of the Bioinformatics unit situated in INGM.

Qualifications
We welcome candidates holding (or about to obtain) a PhD degree in computational biology, bioinformatics and related fields who wishes to join a dynamic and interactive team. You should also have excellent skills in both programming and communication and have a good understanding of biology.

Please apply by sending a letter of motivation describing your interest in this research and past research experiences, a curriculum vitae and names of at least two referees to:

Dr. Alessio Zippo
National Institute of Molecular Genetic (INGM)
E-Mail: zippo@ingm.org

For further informations, please visit the INGM website: www.ingm.org

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PhD position in the Epigenetic Unit

Description
A 3-year PhD position is available starting from September 2012 in the group of Dr. Alessio Zippo at INGM in Milan, Italy. Our newly established team investigates the epigenetic mechanisms that dictate the establishment and the maintenance of stem cell identity. We aim to dissect the molecular mechanisms through which transcription factors mediate the epigenetic responses to environmental signaling in Embryonic and Cancer Stem Cells.
We are seeking highly motivated candidates that will have the opportunity to develop a research project using state-of-the-art of molecular biology/biochemistry technologies and in vivo time-lapse imaging. You will benefit from the possibility to work in close collaboration with all the researchers of the Institute taking part in scientific discussions on a day to day basis.

Qualifications
We welcome candidates holding (or about to obtain) a degree in Biology, Biothecnology or related fields who wish to join a dynamic and interactive team and ready to meet the challenge of an exciting opportunity.

Please apply by sending a letter of motivation describing your interest in this research and past research experiences, a curriculum vitae and names of at least two referees to:

Dr. Alessio Zippo
National Institute of Molecular Genetic (INGM)
E-Mail: zippo@ingm.org

For further informations, please visit the INGM website: www.ingm.org

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Post doctoral position in Cancer Stem Cell Signaling and Epigenetics

Description
A 3-year post-doctoral position is available starting from September 2012 in the group of Dr. Alessio Zippo at INGM in Milan, Italy. Our newly established team investigates the epigenetic mechanisms that dictate the establishment and the maintenance of stem cell identity. We aim to dissect the molecular mechanisms through which transcription factors mediate the epigenetic responses to environmental signaling in Embryonic and Cancer Stem Cells.
We are seeking highly motivated candidates to investigate epigenetic mechanisms controlling the formation of mammary Cancer Stem Cells using molecular biology/biochemistry technologies and in vivo time-lapse imaging.

Qualifications
We welcome candidates holding (or about to obtain) a PhD degree with a strong background in cell and molecular biology who wish to join a dynamic and interactive team. Previous experience in ChIP and ChIP-seq technology and/or stem cell biology will be an advantage but is not essential.

Please apply by sending a letter of motivation describing your interest in this research and past research experiences, a curriculum vitae and names of at least two referees to:

Dr. Alessio Zippo
National Institute of Molecular Genetic (INGM)
E-Mail: zippo@ingm.org

For further informations, please visit the INGM website: www.ingm.org

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Technician position in the Virology Program

Description
A technician position is available in the group of Dr. Raffaele De Francesco at INGM in Milan, Italy. Our team investigates the role of alterations of phosphatidylinositol 4-phosphate (PI4P) metabolism on the pathogenesis of liver disease, with particular focus on HCV and liver cancer.

Qualifications
We are looking for candidates with a strong background in cellular biology and biochemistry, preferably with previous experience of protein purification and enzymatic inhibition studies using biochemical assays.

Please apply by sending a letter of motivation describing past laboratory experiences, a curriculum vitae and names of at least two referees to:

Dr. Raffaele De Francesco
National Institute of Molecular Genetic (INGM)
E-Mail: defrancesco@ingm.org

Dr. Petra Neddermann
National Institute of Molecular Genetic (INGM)
E-Mail: neddermann@ingm.org

For further informations, please visit the INGM website: www.ingm.org

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Post-doctoral positions in Virology Program

Description
3-year post-doctoral positions are available in the group of Dr. Raffaele De Francesco at INGM in Milan, Italy.
We are seeking highly motivated candidates able to design and develop a project and who will participate and contribute to the dynamic exchange of information and discussion within our group. You will have the opportunity to profit and from collaborations with other groups of our Institute. Our institute is continuously growing and offers a modern and “state-of-art” technological platform.
The project will be centered around one of the following topics:

1. Role of phosphoinositol 4-phosphate metabolism and PI4K kinases in the pathogenesis of chronic liver disease and liver cancer;
2. miRNA and ceRNA regulation of PI4K genes during disregulated cancer growth;
   
3. Identification of host and viral genetic determinants implicated in the progression of hepatic and extra-hepatic diseases associated with chronic hepatitis C (e.g. liver fibrosis, cirrhosis, hepatocarcinoma).
   

Qualifications
We are looking for candidates holding (or about to obtain) a PhD degree with a strong background in molecular and cellular biology.  Previous experience in the field of cell-imaging by fluorescence confocal microscopy will be an advantage but is not essential.

Please apply by sending a letter of motivation describing past laboratory experiences, a curriculum vitae and names of at least two referees to:

Dr. Raffaele De Francesco
National Institute of Molecular Genetic (INGM)
E-Mail: defrancesco@ingm.org

Dr. Petra Neddermann
National Institute of Molecular Genetic (INGM)
E-Mail: neddermann@ingm.org

For further informations, please visit the INGM website: www.ingm.org